It happened in the early hours of Wednesday at the junction of Whitby Road and Cromwell Road.
A 23-year-old man from Wirral has been charged with wounding with intent and possessing an offensive weapon in a public place following an altercation in Ellesmere Port.
The charges relate to an incident at the junction of Whitby Road and Cromwell Road in Ellesmere Port shortly before 1am on Wednesday 16 January in which a 27-year-old man from the town sustained a serious head injury.
He was taken via ambulance to the Countess of Chester Hospital, where he continues to receive treatment.
A 24-year-old from Ellesmere Port who was arrested on suspicion of wounding with intent in relation to the incident has been released under investigation pending further enquiries.